The placebo effect is mind over matter. The subtle energy system of the body is intimately connected to mind and matter. The energy responds to mind and influences matter. I believe this energy is the interface between the two. I also believe that the placebo effect is possible because of this energy. Despite all of the mapping research done into the brain memories and consciousness cannot be isolated. Our society and culture predominately uses the words 'mind' and 'brain' interchangeably, but the two appear to be entirely different and separate from each other. The brain would be the physical organ that is the hub and command center of the central nervous system and the mind would be non-physical, energetic in nature, and the seat of your memories/consciousness/awareness. It isn't my intent to get too deep and philosophical here, but I'm trying to illustrate a different frame of reference through which to consider viewing the mind's influence on health. The body's subtle energy system is not a nebulous concept. It has been mapped for thousands of years. Energy pathways are consistent and identical from person to person. Modern electronic devices can now measure and detect acupuncture points that were known thousands of years ago when such technology was not available. These energy pathways serve a very real purpose and work in the background to influence the physical body as it responds to your thoughts, emotions, beliefs, and intentions. It works whether you are aware of its existence or not, just as the rest of the universe does. The only difference is that when you acknowledge something and learn about it, you can then use it to your advantage. There is a quote by T. H. Huxley that I really like. It says, "Sit down before fact like a little child, and be prepared to give up every preconceived notion. Follow humbly wherever and to whatever abyss Nature leads, or you shall learn nothing." You just might be amazed at what you discover if you keep an open mind. While it is beneficial to maintain healthy skepticism and use discernment, skepticism ceases to be healthy when you close your mind to new concepts just because you don't want to consider them. It's a fine balance really and can be difficult to maintain.