My expierence was just while taking the Prednisone. About halfway into the dose, my whole body would ache, like when you have the flu. After the medication was out of my system, the aches would go away, until I took the next dose. I dont remember exactly how long after I stopped the Prednisone that the twitching started. It could have been immediately, it could have been a couple weeks. I didnt pay much attention to the twitches when they 1st started.So, as I said in your other post, no one knows if Prednisone has anything to do with BFS. There are many more people who didnt have problems with Prednisone, and twitch, than those of us who did. What I do know, is Prednisone is a nasty nasty medicine...and I wont be taking it again unless its life or death.~*~Amy~*~