DrugResistance
Well-known member
Anyone heard of this....COUSIN OF NEURONTIN
Relatively NEW - Sept 04....
Was reading about it for FIBRO.....
Relatively NEW - Sept 04....
Was reading about it for FIBRO.....
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New Medication for Fibro?
- Thread starter DrugResistance
- Start date
DrugResistance
Well-known member
FDA Approves Lyrica (Pregabalin) for Treatment of Neuropathic Pain
NEW YORK, NY -- January 3, 2005 -- Pfizer Inc has received approval from the U.S. Food and Drug Administration (FDA) to market Lyricaâ„¢ (pregabalin capsules) for the management of neuropathic pain associated with diabetic peripheral neuropathy (DPN) and postherpetic neuralgia (PHN). Lyrica is the first FDA-approved treatment for both of these neuropathic pain states, which are distinctly different from arthritis or musculoskeletal pain.
Developed by Pfizer, Lyrica has a newly defined mechanism of action. Lyrica will be available to physicians and patients in the near future.
"Lyrica is an important new therapy for millions of people suffering from the two most common neuropathic pain conditions as it provides rapid and sustained pain relief," said Dr. Joseph Feczko, president of Worldwide Development at Pfizer. "Lyrica also represents a major achievement in Pfizer's research program and confirms our leadership in bringing life-changing medicines to patients."
Neuropathic pain, one of the most debilitating forms of pain, is caused by nerve damage that can result from underlying conditions, such as diabetes or shingles. Nearly half of the 18 million Americans with diabetes will develop some form of diabetic neuropathy over the course of their disease and about one in six diabetes patients will experience painful diabetic neuropathy. The pain of DPN is often described as burning, tingling, sharp, stabbing, or pins and needles in the feet, legs, hands or arms.
PHN is a complication of shingles, a painful outbreak of rash or blisters on the skin caused by a reactivation of the same virus that causes chicken pox. Each year, about 150,000 Americans develop PHN, which is often characterized as constant stabbing, burning, or electric shock-like sensation.
The efficacy of Lyrica was established in six double-blind, placebo- controlled trials, three involving patients with DPN and three involving patients with PHN. Lyrica provided rapid and clinically meaningful pain reduction in a significant portion of patients, with pain relief beginning as early as the first week of treatment in some patients. Pain relief was sustained in studies of up to 12-weeks duration.
The safety of Lyrica was established in over 9,000 patients. In all clinical trials, adverse events were mild to moderate. The most common side effects associated with Lyrica compared with placebo included dizziness, somnolence, dry mouth, peripheral edema, blurred vision, weight gain and difficulty with concentration/attention. The discontinuation rate due to side effects was low.
Lyrica is expected to be classified as a controlled substance in a category with lower potential for misuse or abuse relative to controlled substances in other categories.
Lyrica is currently under review by the FDA for the adjunctive treatment of partial seizures in adults. In July, Pfizer received European Commission approval to market Lyrica in European Union member states for the treatment of peripheral neuropathic pain and as adjunctive therapy for partial seizures.
SOURCE: Pfizer Inc
NEW YORK, NY -- January 3, 2005 -- Pfizer Inc has received approval from the U.S. Food and Drug Administration (FDA) to market Lyricaâ„¢ (pregabalin capsules) for the management of neuropathic pain associated with diabetic peripheral neuropathy (DPN) and postherpetic neuralgia (PHN). Lyrica is the first FDA-approved treatment for both of these neuropathic pain states, which are distinctly different from arthritis or musculoskeletal pain.
Developed by Pfizer, Lyrica has a newly defined mechanism of action. Lyrica will be available to physicians and patients in the near future.
"Lyrica is an important new therapy for millions of people suffering from the two most common neuropathic pain conditions as it provides rapid and sustained pain relief," said Dr. Joseph Feczko, president of Worldwide Development at Pfizer. "Lyrica also represents a major achievement in Pfizer's research program and confirms our leadership in bringing life-changing medicines to patients."
Neuropathic pain, one of the most debilitating forms of pain, is caused by nerve damage that can result from underlying conditions, such as diabetes or shingles. Nearly half of the 18 million Americans with diabetes will develop some form of diabetic neuropathy over the course of their disease and about one in six diabetes patients will experience painful diabetic neuropathy. The pain of DPN is often described as burning, tingling, sharp, stabbing, or pins and needles in the feet, legs, hands or arms.
PHN is a complication of shingles, a painful outbreak of rash or blisters on the skin caused by a reactivation of the same virus that causes chicken pox. Each year, about 150,000 Americans develop PHN, which is often characterized as constant stabbing, burning, or electric shock-like sensation.
The efficacy of Lyrica was established in six double-blind, placebo- controlled trials, three involving patients with DPN and three involving patients with PHN. Lyrica provided rapid and clinically meaningful pain reduction in a significant portion of patients, with pain relief beginning as early as the first week of treatment in some patients. Pain relief was sustained in studies of up to 12-weeks duration.
The safety of Lyrica was established in over 9,000 patients. In all clinical trials, adverse events were mild to moderate. The most common side effects associated with Lyrica compared with placebo included dizziness, somnolence, dry mouth, peripheral edema, blurred vision, weight gain and difficulty with concentration/attention. The discontinuation rate due to side effects was low.
Lyrica is expected to be classified as a controlled substance in a category with lower potential for misuse or abuse relative to controlled substances in other categories.
Lyrica is currently under review by the FDA for the adjunctive treatment of partial seizures in adults. In July, Pfizer received European Commission approval to market Lyrica in European Union member states for the treatment of peripheral neuropathic pain and as adjunctive therapy for partial seizures.
SOURCE: Pfizer Inc
pilotproblems
Member
Jumping in...
I was on Nuerontin for 2 weeks at 900mg (3 x 300). It really did nothing for me. Actually made me a bit sick feeling and tired.
I switched to lyrica and now take 3 x 75mg a day. Doctor says max I can take is 5 a day. Anyhow, I take it for neuropathic pain and though it has not 100% cleared the pain, it has dropped it to the 0 -20% range at times.
So it is a success for that, but it did not work for any of my twitiching and I have no side effects from it at all--which is lucky.
I was on Nuerontin for 2 weeks at 900mg (3 x 300). It really did nothing for me. Actually made me a bit sick feeling and tired.
I switched to lyrica and now take 3 x 75mg a day. Doctor says max I can take is 5 a day. Anyhow, I take it for neuropathic pain and though it has not 100% cleared the pain, it has dropped it to the 0 -20% range at times.
So it is a success for that, but it did not work for any of my twitiching and I have no side effects from it at all--which is lucky.
0nDonkeyPowerPornopo
Well-known member
wow..has it been that long ago since i posted that....
all i can say is this....
i still twitch
i don't take any meds
it gets worse with stress and exercise and lack of food
i have run THREE marathons since.....
i often think about the worst....but, why...you can't control any of it....
please don't obsess over this unless you are weaker, and are wasting away...........it has been roughly four years.......and all is well otherwise with my health
my best to everyone who lets this take them away from life mentally
peace
all i can say is this....
i still twitch
i don't take any meds
it gets worse with stress and exercise and lack of food
i have run THREE marathons since.....
i often think about the worst....but, why...you can't control any of it....
please don't obsess over this unless you are weaker, and are wasting away...........it has been roughly four years.......and all is well otherwise with my health
my best to everyone who lets this take them away from life mentally
peace
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