2) Lead toxicity Researching PNH Symptoms

[flynnel]

This is a follow-up of my posting on what worked for me as a subset of those with BFS or PNH like myself. For those inclined to researching the medical reasons why PNH is a comglomerate of symptoms for your condition, consider the following. Please don't be intimidated by going to: The National Library of Medicine and the National Institutes of Health :

PubMed:

Consider these:

1) Hypothyroidism Presenting With Musculoskeletal Symptoms by D. N. Golding, Ann. Rhem Dis (1970), 29, 10 (full pdf available)

2) Neuromuscular Findings in Thyroid Dysfunction: A Prospective Clinical and Electrodiagnostic Study by Ruurd F Duyff, et al, J Neurol Neurosurg Psychiatry 2000; 68: 750-755 (full pdf available)
(note: problem with both hyperthyroidism and hypothyroidism)

3) Neuromuscular Hyperexcitability Features in Patients Suffering from Musculoskeletal Pain: a Neuroepidemiologic Survey by P H Jansen, et al, Funct Neurol. 1992 Jan-Feb; 7 (1): 31-4 (abstract only)

4) Evidence of Neuromuscular Hyperexcitability in Patients with Primary Fibromyalgia by C Vitali, et al, Clin Exp Rheumatol 1989 Jul-Aug; 7 (4): 385-90 (abstract only)

5) Evaluation of the Patient with Muscle Weakness by Aaron Saguil, et al, American Family Physician, April 1, 2005, Vol 71, Number 7
( full pdf available)

6) Reversible Subclinical Hypothyroidism in the Presence of Adrenal Insufficiency by Hussein D. Abdullatif, MD, Endocrine Practice Vol 12, No. 5 Sept/Oct 2006 (full pdf available)

7) Autosomal-Dominant Non-Autoimmune Hyperthyroidism Presenting with Neuromuscular Systems by Aziz Elgadi, Acta Paediatrica, Vol 94, No. 8/Aug 2005 (abstract only)

The Treatment of Myotonia: Evaluation of Chronic Oral Taurine Therapy by Luca Durelli, MD, Neurology 1983; 33: 599 (abstract only)

(note: L-taurine is a non-essential amino acid (protein) for humans but may be helpful: this is one that I'm trying on my one as well as both pyridoxine (vit B6) and thiamine (vit B1) at 100 mg or less per day and am considering the amino acid, glycine; use of alpha-lipoic acid is the best way to increase glutathione as the best antioxidant in the human body; acetyl-L-carnitine is another nutrient to consider, as well as the omega-3 fatty acids - DHA and EPA; resveratrol is another as a polyphenol with great possibilities in the future)

9) Muscle Carnitine in Hypo- and Hyperthyroidism by C. Sinclair, et al, Muscle Nerve. 2005 Sept; 32 (3): 357-9 (abstract only)

10) The Immune System as a Regulator of the Thyroid Hormone Activity: Minireview by John R. Klein, 2006 Society for Experimental Biology and Medicine ( thought to be available as full pdf)

11) A Metabolic Basis for Fibromyalgia and Its Related Disorders: the Possible Role of Resistance to Thyroid Hormone by R. L. Garrison, P.C. Breeding, Medical Hypothesis (2003) 61 (2), 182-189 (abstract only but applicable to PNH and very thought provoking)

12) Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action by Andrew V. Turnbull and Catherine L. Rivier, Physiological Reviews, Vol 79, No. 1, Jan. 1999, pp. 1-77 ( full pdf available)

13) Dissociation Between Reactivity of the Hypothalamus-Piuitary-Adrenal Axis and the Sympathetic-Adrenal-Medullary System to Repeated Psychosocial Stress by Nicole C. Schommer, et al, Psychosom Med. 2003 May-Jun; 65 (3): 450-60 (full pdf available)

14) Exhaustion is Associated with Reduced Habituation of Free Cortisol Responses to Repeated Acute Psychosocial Stress by Biol Psychol 2006 May; 72 (2): 147-53 (abstract only)

15) Allostatic Load, Perceived Stress, and Health: a Prospective Study in Two Age Groups by J Hellhammer, et al, Ann N Y Acad Aci. 2004 Dec; 1032; 8-13 (abstract only unless a member of the New York Academy of Sciences; subscription USD$95/year and best place for me to get thorough up-to-date information)

16) Hypothalamic-Pituitary-Adrenal Axis Function in Sjogren's Syndrome: Mechanisms of Neuroendocrine and Immune System Homeostasis by Elizabeth O. Johnson, et al, Ann. N. Y. Acad. Sci. 2006, 1088: 41-51 (abstract only unless member, applicable to BFS and PNH conditions)

17) Corticotrope Hypersecretion Coupled With Cortical Hypo-Responsiveness to Stimuli is Present in Patients With Autoimmune Endocrine Diseases: Evidence for Subclinical Primary Hypoadrenalism? by Roberta Giordano, et al, European Journal of Endocrinology, Vol 155, Issue 3, 421-428 2006 (full pdf available)

This is only a beginning of any good research relating to situations with low-grade hypocortisolism - low-grade hypothyroidism - benign fasciculation (cramp) syndrome - neuromyotonia - peripheral nerve hyperexcitability - fibromyalgia - chronic fatigue syndrome - myalgic encephalomyelitis (for me, they are all related; they are on a continuum and as part of aggregate broad syndrome relating to cortisol, thyroid, serotonin, potassium channelopathies, potassium - calcium - magnesium - pyridoxine - thiamine - B12 - selenium - copper - vitamin E - immune upregulation- disregulation, pro-imflammatory and anti-imflammatory cytokines, leukotrienes, Th1 (T helper 1 cells), Th2, and Th0 cells; to name a few, the list goes on and one)

Sorry about this for going on and on. Do check from my first post on what actually has worked for me: the hormones - Cortef (cortisol) and T4/T3 (thyroid) medication.

 

[eyennyGlimmer]

ummmm thanks for all the info- but me not reading, I will freak..lol ) but thank you, if i ever get brave I will read it.

Sorry to hear about all your health conditions, are you taking anything, like all of those supplements you mentioned? or?..Jenn

 

[eyennyGlimmer]

sorry, I just saw your other post and saw what you are taking now to help..Jenn

 

[haremu]

I had graves disease when I was younger and one of my symptoms back
then was twitching alot of it once we got it under control it stopped. I also
had a fast pulse and shakes with sweaty palms and irregular heart beat.
though graves disease is not hypo its hyper once its hyper like that it can
fall hypo so I had to be checked for six months regularly. It is something for some to look into.

DStar

 

[furballfury]

I have believed for some time that the body of knowledge you are pouring into here is right on point with what's going on with us. I personally know that for me, adrenal function has not been normal for quite some time (high cortisol test results, varying abnormal thyroid panels, significantly lowered testosterone results, slightly elevated liver function panels which have now suddenly dropped back into normal range, etc.)

All of this started happening right around the same time my BFS cropped up, as did the increase in incidences of odd maladies, infections, etc. I believe I literally fried my wiring/system and burned myself out with work, family, personal stresses, and that tipped me over an "edge" I may not recover from (e.g.: this BFS symptom regimen). That said, I've noticed infinite improvements in my symptoms and their severity after finally learning how to really cope with this and anxiety overall, get better sleep, eat better, cut out the caffeine and other cr*p, and stop drinking. Obviously, in tandem, these things ALL support better overall adrenal health, and can only be moving me in a positive direction. That is what I focus on, and the rest of the "chips" can fall where they may.

The hormonal and endocrine functions within the body are overall so poorly understood in general medical practice, and it is quite likely that this type of syndrome could be housed within this medical area and overlooked. Good work compiling such an impressive list of documents, and I hope their contents help you.

JG

 

[flynnel]

Thanks furballfury. I think that I understand your situation quite well because it's similar to my own. I do think that there is hope and things can be turned around for you. Why? Because for 4 years now I've found something that has worked. Please take a look at the lab test results that I received from a laboratory today and the data that I in turn posted with the string associated with my first post here. For the cost involved, I received an abundance of information from them. It simply was a kit purchased through the The CanaryClub.org that I only in the last month became acquainted with.