i am not sure that BFS is auto-immune mainly because there already is an auto-immune disease that attacks the nervous system!! It is caused multiple sclerosis!! Any auto-immune disease generally causes inflammation on the area that it attacks Lupus, MS, Crohns, Rhematoid Arthritis etc etc which is normally takes a long time to heal 3 months even with the help of steriods. Unless i am mistaken generally BFS symtoms are normally fleeting okay we all get the occasional hotspot with the popular areas being eyelids, calfs, feet archs and triceps but nothing suggesting inflammation. Also because we are all generally very health aware most people on here have all had MRI's, CAt scan EMGs all of which would pick up inflammation on the nervous system. From what i can see on here 95% of people have normal test and neuro examinations.I am certain BFS is not autoimmune but instead an over active nervous system. The nervous system communicates with the body in two ways - via chemicals called hormones and by electrical impulses that travel at a speed of 130 metres per second, when you are stressed this is increased to give you a chance to run away from that big lion that is about to eat you or fight the bloke in the pub that is chatting up your wife! Too much of this and your body becomes overloaded with Excess cortisol which interferes with mood enhancing neurotransmitters called serotonin. Disturbances in serotonin levels can be a factor in causing clinical depression and anxiety disorders i.e. health anxiety which makes the whole problem worse and hence you are in a vicious circle resulting in more stress. After a while your nervous system is in constant high alert and these electrical inpulses become too high resulting in muscle twitching, buzzing, migraines, muscle pain etc etc I firmly believe this is what most of us here have but i think once the nervous system has been stressed it almost is damaged and can take a long time to recover hence the reason why alot of us on here have been twitching/buzzing/tingling for years. There seems to be a link between this and viral infections and i cannot really think of a reason why that is....i had mumps about 3 months before my BFS started and does make you wonder but maybe a virus just makes your nervous system more sucesiable to being hyperactive. I think we will never know for sure as even top doctors dont really understand the nervous and immune system despite what they claim, and no one really is bothering investigating this BFS as most people dont reconise it as an actual illness or disease as it doesnt cause any disability which is something i think all of us should be very grateful for. Good luck and happy twitching......