YES, cannabis DOES help twitching. I am in the process of receiving my degree in organic chemistry at my college and I've read many chemistry journals on this subject exhaustively. The short, simple answer without all the mumbo-jumbo put into layman terms is THC, the primary active constituent in cannabis binds to most cannabinoid receptors resulting in muscle relaxation. I can also testify from direct personal experience.It is prescribed in some countries for epilepsy and to a lesser degree twitching. I know a few epileptics who can attest to this as well.As for the negative sides of Cannabis?...none. besides getting arrested. erowid.org is an amazing organization that documents the effects of MANY psychoactive substances which is an incredible vault for information.on a side note, a general rule(however everyone is different):stimulants=twitching++ ( huge threshold in twitching)depressants=twitching- (marked decrease in twitching)anti-anxiolytic(anxiety meds ex: Valium(Diazapam),Klonopin(Clonazapam),Xanax(Alprolozam)=twitching--- (way less twitching)hallucinogens(cannabis,LSD, Psilocybin mushrooms, DMT, mescaline)=twitching-- (not quite as effective an benzoepidine's/anti-anxiety yet much more effiecient than depressants such as alcohol)hope that helped. for any related pharmaceutical questions you can PM me since it is my field of expertise and i'm more than welcome to aid.