Calcium and Magnesium are going to help the best when it comes to muscle related things, like twitching. The thing is though, if you dont get the right combo, (they need to be taken with Vit C as well) you dont get the proper absorption. If you are going to go this route, (the natural way is the route I chose, and there are lots of natural things to do, dont get me started lolol...I do not take any Doctor prescribed meds other than an allergy nasal spray which is not related to BFS obviously) then make sure you get a really good high quality, high potency supplement. I take a product called Cal 6 + Mag. It has the Calcium and Magnesium in it, plus the Vit C and other stuff that is needed in order for your body to property absorb the Calcium and Magnesium. If you dont get a high quality supplement that has these other things in it, you will be taking it in vain because it will just pass through your body.~*~Amy~*~