Simple understanding of the fact that twitch is a muscle activity helps understand that pain should be a normal result. Usually you twitch in a muscles which othrwise are not operated, at least not at that way. So you have natural soreness in them due to twitching.MS is ruled out on the basis of a) lack of clinical symptomes of acute demyelinisation, often manifested as neuritis, b) absence of leisons in the white matter in certain regions of brain and spine (MRi), c) in the presence of leisons (which many people have due to age-realted demyelinisation) - lack of temporal and spatial spreading in the course of 4-6 month. Some immunoglobilnes might be present in the spinal cerebral liquid but not always. VEP in case of suspicious optical neurinits and neuroconduction study for overall conduction arealso useful.but localised pain clearly associated with twitches usually does not point to MS at all, rather to BFS.as for magnesium deficiency you asked in the previous post, one can say it is a vague matter. Many of fellows complain for having been found very low in B12. B12 seems not to be directly related to Mg (it is rather another B vitamine, B6, used for better digestion of Mg in the artificial supplements), but still same group, common reactions etc. So probably we may be also low on Mg. Or - I think - it might be that normal level of Mg are physiologically low for us becasue we can not balance it right due to changes in body chemistry. I had perfect middle range Mg all the time I did the test, and it does not prevent me from awful series of cramps pretty much relieved with Mg supplement intake. So I think that maybe my own personal normal Mg level has to be somewhat higher than normal in order to keep normal level for muscle operation without cramps.