I had some relief from magnesium citrate, but it was short lived and just gave me IBS issues so I had to stop it. I also tried "Natural Calm" (which is easily absorbable magnesium) but it gave me restless legs and made me hyperactive for about two hours after taking it. My biggest "natural" mistake was taking l-theanine, a natural pre-cursor to GABA. I don't know if you'll react to it like I did, but it's supposed to decrease anxiety and be a natural muscle relaxer. For me, it made me very hyperactive, increased my anxiety, and immediately worsened my already bad symptoms. The only supplement I can confidently recommend is Source Natural's Wellness Tabs. They don't do **** for twitching, but they do keep you from getting ill from insomnia.