I get this too. Thumbs, pointer, index, ring and pinky...both hands!! They jerk up, jerk down, wiggle side to side and any other way they can possibly twitch. I HATE it! At my first neuro appointment, the neuro induced Hoffman's sign in my hand that is why he gave me a cervical spine MRI. All he said was it was an indicator of spinal issues, not anything sinister necesarrily. My cervical spine MRI did show a bulging disc, 3 bone spurs and a spinal cord defect, (likely born with it, or injury caused, no way to know for sure) All of these can cause twitching if bad enough, but I have had two neuros say they weren't bad enough to be causing my twitching for some reason.... go figure....j_sageurge, I see you are a saint on here...hope you don't mind if I PM you sometime?? I am a newbie, only 11 months in, so still can get pretty freaked.Tanya