The entire palms of my hands look pruned. I have been diagnosed with carpel tunnel. Also I am in my fifties and believe I am losing collagen which makes the hands look more wrinkled. I have gone to doctors and complained about how my hands look and I get no response or concern. One doctor said, "Look at my hands. They're worse than yours." But he looked quite a bit older than me.There was one female doctor who kept pushing on my wrists and watching the blood flow back into my hands and she thought there was a problem and referred me to a vascular surgeon. I have not had that appointment yet, but I also have these fatty lumps on my wrists called ganglions which I believe may be interfering with the circulation to my hands. I have decided not to be too concerned.Sandra D