I have a 24/7 calf as well, I cannot really say it is painfull, not severe anyways. One thing I do for my calf, it I roll up my blue jeans tight up below the knee, I do not know why, but it provides some relief to the area, or it changes the sensation of the twitching. I do this when I am sitting at my desk, driving or hanging around the house. I think I may be starting a new fashion craze, as my daughters will walk around the house with one pant leg rolled up.