bdaddyjohnson
Active member
PLEASE READ THIS RESEARCH IF YOU HAVE TAKEN ANY OF THESE ANTIBIOTICS PRIOR TO ONSET OF YOUR SYMPTOMS FEEL FREE TO COMMENT ON YOUR EXPERIENCES!!! I THINK THIS IS THE CAUSE OF ALL MY SYMPTOMS>>>>>>>>>It is well known and accepted that severe cases of quinolone toxicity are distinctive for the high level of toxic myopathy (muscle abnormality) developed by all floxed persons. But the quinolones have been conceptually sold to the prescribing doctors like the perfect antibiotic when in fact they cause devastating, long lasting (for years, and many times permanent) myopathies and motor neuron disorders. On the other hand, many other drugs have been clearly associated with muscular toxicity (AZT with mitochondrial myopathy; corticosteroids with myosin deficiency myopathy; statins and cyclosporine with rhabdomyolysis; etc…). A very worrying symptom that many people experience as part of their strong reactions is muscle twitching. Twitching can be of very different types, but could be simply classified as: Fibrillations, imperceptible fasciculations, only detectable by electric devices. They are characteristic of inflammatory myopathies and denervation. They are spontaneous action potentials in a single muscle fiber, not visible on physical examination. Physically they last 1 to 5 miliseconds in duration and their firing rates is between 1 to 30 per second, being 13 on average, and are usually quite regular. Increase in conditions of muscle warming. The cause is a decreased resting membrane potential in the denervated muscle. Fasciculations: long wave movements, crawling under the skin, very visible palpitations of the muscles. They are a spontaneous discharge of an axon causing contraction of muscle fibers in rippling unit and produce visible rippling of muscle. May originate anywhere along the course of the axon. In floxed persons they are a consequence of the motor neuron injuries caused by the toxicity of the quinolones. Once again, they are exacerbated by caffeine (that floxed persons cannot metabolize) and some drugs like theophylline or lithium. Fasciculations: short wave movements, a sort of buzzing of the flesh, perceived by the victim, but not easily visible. They are identical to the long wave fasciculations, but with a lower amplitude. Twitching is a muscle reaction to abnormal nerve firings. There is a type of benign fasciculations but in floxed persons it is a symptom of neurological damage. In many floxed persons it starts in the eyelids and hands, but it is very common to have them in arms and legs. It is accompanied by a certain degree of weakness with no true prominent atrophy, especially in arms and legs. Areas plagued with fasciculations have normal sensory feelings. Fasciculations move from one part of the body to another and some days have a long wave amplitude and other days a short wave one. Normally the fasciculations are asymmetric at any given time. Some electromiograms of floxed persons have shown discreet signs of demyelination--without conduction blocks. The fasciculations become chronic for months or years. Not more than two of the 42 floxed persons studied in cohort of table 1 have had in common any serum antibody consistently elevated or abnormal. In fact, 97% overall of the serum analysis and antibodies in those subjects have not shown any abnormality, and those out of range readings have revealed a return to normalcy in further tests. Many times, twitching is also accompanied by muscular cramps, especially in the gastrocnemius and other areas. Cramps are sometimes induced by exercise or touching the muscle and they can spread along the transverse direction across the muscle. Tendon reflexes are normal. Twitching does not usually develop in mild reactions. It is a typical symptom of intermediate and severe reactions. It starts any time from during the treatment up to several months later. Fasciculations and/or cramps are early symptoms of myastenia gravis, or amiotrophic lateral sclerosis, for instance. That is why these symptoms are so distressing especially when they last for years on end and are always ever present in daily life. Many severely floxed persons that take magnesium feel their fasculations increase, as well as their muscular pains (interestingly enough, magnesium is a well known counterindication in myastenia gravis and other muscular autoimmune disorders). Again, in all these cases, serum CK may be mildly elevated. Six biopsies performed on five floxed persons have all shown loss of small caliber end-axons and less density of nerve endings. None of these floxed persons tested positive for antibodies to skeletal muscle, nor did the biopsies show any inflammation or lymphocytic proliferation. Other biopsies of floxed persons revealed axonal inflammation (swelling). Some reports received from floxed persons tend to suggest that fasciculations that show up late in the reaction (one to three years) might herald the onset of a recovery in myofascial and neuropatic pains. Not enough conclusiveness though about this point.
OK that sounds like a start. I've just done a couple of internet searches, however mainly German sites. Besides the "normal" possible side effects (like headache, nausea, diarrhea) Fluoroquinolones were reported to increase the danger of tendon ruptures, especially when consumed by elderly people. Another extremely strange thing I found was that the suicide rate among patients taking Fluoroquinolones is higher than usual. How can an antibiotic make somebody kill himself? This isn't even any sort of psychopharmacological stuff, it's a stupid antibiotic... Well, these are the reasons why many Fluoroquinolone-based antibiotics were taken from the market, according to German Wikipedia. However, Ciprofloxacin and some others are still being sold. I haven't found anything specific on fascis yet...And well, I must admit, I'm really scared now... Does this possibly mean that the antibiotic has started killing our nerves over time and the we might end up the same way as an **S-patient? Or... is this all somehow even related to **S? I mean, your post says that the twitching in floxed persons is a result of neurological damage as opposed to BFS. What exactly does "floxed" actually mean? Is a floxed person somebody who has once taken a Fluoroquinolone antibiotic?