Cramp Fasciculation Syndrome goes by many names. Sometimes people with Benign Fasiculation Syndrome will experience just twitching and not cramping, but that doesn't mean they're different disorders. One person I know from the BFS site didn't start having cramping until a year after her BFS diagnosis and she doesn't get cramps very often now.J Newsom-Davis discovered the antibodies that cause Cramp Fasciculation Syndrome. An autoimmune reaction causes the antibodies that interfer with voltage-gated potassium channel (VGKCs) causing the symptoms which can vary in both intensity and frequency. Many neurologists have never heard of Cramp Fasciculation Syndrome because it's not that common and, for those who have heard of it, testing for the VGKC antibodies doesn't occur that frequently. Patients may or may not test postitve for the antibodies. They may also test positively at one time and then be retested and find negative results. Here is a small portion of an article by J Newsom-Davis describing some research findings;Acta Neurol Belg (2005) 105: 181-6. Neuromuscular junction channelopathies: a brief overview. J Newsom-DavisUniversity of Oxford, Department of Clinical Neurology, Oxford, UK. .....Neuromyotonia (NMT) and Cramp-Fasciculation syndrome (C-FS) are manifestations of peripheral nerve hyperexcitability and share some clinical and electromyographic features. Antibodies to voltage-gated potassium channels (VGKCs) are present in about 40% of NMT patients, but less frequently in C-FS, and appear to cause loss of functional VGKCs. ......The antibodies described here provide valuable aids to diagnosis and management.For much more complete information go to
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