My 2nd major relapse started with lifting heavying plastic grocery bags with my left thumb and index finger. After that they just kept twitching, more so when I lifted something heavy with that hand. My original neurologist had retired and I had been in remission for several years, so went to an orthopedic doctor who referred me to another neuro. I remember him telling me that he didn't think it was serious since I had experienced twitching in other areas before. Long story short, it remained a hotspot for months, and the twitches spread. 2nd neuro said my clinical was fine, he did do an EEG because the twitching was only in those fingers AT FIRST when I went to him---it was normal. I continued going to him on and off for years until I moved out of state (when I felt I needed to run a new symptom by him.) Best Wishes, Denise