Here we go again--trying to read the tea leaves about what possible sinister cause lies behind the twitching based on some "study" or, in this case, if someone is over 45. Guess I'm sensitive to that because I'm 48 and my twitching started nearly 6 months ago when I was. . . 48. The point here is that this kind of speculation gets folks wound up, just like those posts about "X seconds between twitches means they're bad" or "twitches that occur every second Thursday are clearly related to NMD." It is a fact that ALS strikes mainly people age 50 or 60 and up, but even then, it remains a rare disease, period. So, keep context in mind--weakness? No. Wasting/atrophy? No. Clinical/progressive weakness? No. Good clinical exam? Yes. Clean EMG/other tests? Yes. Doctors annoyed with your obsessing? Hell yes. If that's your situation, I don't care if you're 95 and twitching, your OK. It's benign. Stop looking for the Four Horsemen of the Apocalypse in that cloud overhead; looks like a freakin' rabbit to me.Let's get back to focusing on the big picture, not a paper or study that portends doom. That's not what this site is for.My 200 cents' worth.Mark